A Model for Efficient Assay Development and Screening at a Small Research Site

Creating an automated assay team with multiple skills that can support diverse screening responsibilities is a key challenge for drug discovery research sites. Development of ultra high throughput screening (uHTS) screens, development of lead identification and lead optimization assays within medicinal chemistry supported projects, and automation and miniaturization of assays are best performed by a dedicated team of varying backgrounds, experience, and skill sets. This article discusses how integration with therapeutic franchises, regular communication processes, and formal and informal cross-training facilitate the establishment of a streamlined and efficient model at our site for supporting multiple projects at relatively modest financial outlay and recruitment levels.