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Volume 14, Issue 6, Pages 360-366 (December 2009)


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Automation of the SomaLogic Proteomics Assay: A Platform for Biomarker Discovery

Tracy R. Keeney1, Christopher Bock1, Larry Gold12Corresponding Author Informationemail address, Stephan Kraemer1, Bridget Lollo1, Malti Nikrad1, Martin Stanton1, Alex Stewart1, Jonathan D. Vaught1, Jeffrey J. Walker1

At SomaLogic, we have embarked on an ambitious program of clinical studies using a novel aptamer-based proteomics technology to discover biomarkers and develop new tools to diagnose, understand, and treat human disease. As part of this program, we designed and implemented an automated assay for its highly multiplexed proteomics discovery platform. The performance of the automated assay was validated in a study that compared the automated assay to the specifications of an established manual method. Results showed that the automated method performed to the required specifications, and that the automation system improved the efficiency, productivity, and economics of our biomarker discovery program.

1 SomaLogic, Boulder, CO

2 University of Colorado, Boulder, CO

Corresponding Author InformationCorrespondence: Larry Gold, Ph.D., Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309. SomaLogic, 2945 Wilderness Place, Boulder, CO 80301; Phone: +1.303.625.9000; Fax: +1.03.545.2525

PII: S1535-5535(09)00101-4

doi:10.1016/j.jala.2009.05.003


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